Neonatal group B streptococcal disease: from pathogenesis to preventive strategies

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Pathogenesis of neonatal group B streptococcal infections.

Infections of the neonate due to the group B Streptococcus have been recognized since the 1930s, but it was during the 1970s that their incidence grew alarmingly throughout the world. A research effort stimulated by this problem has yielded significant new information about many facets of the pathogenesis of these infections. Immunologic investigations have pinpointed a lack of transplacentally...

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Prevention of Neonatal Group B Streptococcal Disease

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial Group B streptococci (GBS) are facultative anaerobic, gram-positive cocci that colonize the gastrointestinal and urogenital tracts of humans. GBS strains are serologically divided into 10 types (Ia, Ib, and II through IX) according to their capsula...

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Neonatal group B streptococcal meningitis.

Bacteriological and clinical data on 68 children with neonatal group B streptococcal meningitis were analysed as part of a wider study of bacterial meningitis undertaken between 1976 and 1982. Twenty five per cent of patients died and there was no difference in the mortality rate between early and late onset disease. Sixteen per cent of the infants weighed less than 2500 g at birth but in 50% n...

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Neonatal group B streptococcal disease associated with infected breast milk.

Premature triplets each developed late onset group B streptococcal disease over a period of nine weeks. The source of the organism appeared to be expressed maternal breast milk, in the absence of clinical mastitis. Asymptomatic excretion of group B streptococcus in breast milk may be an under-recognised cause of neonatal infection.

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Prevention of early-onset neonatal group B streptococcal disease.

Most cases of neonatal group B streptococcal disease with early onset have an intrapartum pathogenesis. Attack rates are increased substantially in infants born to mothers with prenatal group B streptococcal colonization and various perinatal risk factors (premature labor, prolonged membrane rupture, or intrapartum fever). In a randomized controlled trial, we studied the effect of selective int...

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ژورنال

عنوان ژورنال: Clinical Microbiology and Infection

سال: 2011

ISSN: 1198-743X

DOI: 10.1111/j.1469-0691.2011.03576.x